How to Perform IVIVC for Extremely Long Acting Drugs
In vitro-in vivo correlation (IVIVC) is a predictive mathematical tool that describes the relationship between an in vitro property of a drug dosage form and an in vivo pharmacokinetic response. Drug developers frequently use this approach to waive the requirement to show evidence of in vivo bioavailability or bioequivalence if the equivalent in vivo performance can be predicted from appropriate in vitro data. A meaningful IVIVC can help guide formulation and/or process development changes in the various stages of drug product development. In addition, an IVIVC can support and/or validate the use of an in vitro dissolution method and can help set clinically relevant dissolution specifications to ensure product quality.
This webinar will investigate the use of in vitro and in vivo models to find direct time scaling factors and confirm the similarity of the in vitro and in vivo release mechanisms.
Speaker(s): Professor Jean-Michel Cardot, Auvergne University
Date: Wednesday, March 27, 2019
Time: 11:00 am EST
Duration: 1 hour